I understood the requirement, I have 9years experience in epub, xml, html tool handling. I can do this through Perl script.
Perl script tool will be faster comparing to other technology.
Tool description:
Tool will get the epub path location from command line.
It reads all the epub opf metadata information and will listing the excel sheet.
You can update the excel sheet then re-run the tool with excel.
It will update metadata information in less than a minute.
If you interested, I will release a demo version of tool to your usage and testing.